Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

Radiation therapy (RT) plays a key role in curative-intent treatments for head and neck
cancers. Its use is indicated as a sole therapy in early stage tumors or in combination with …

Importance Concurrent chemoradiotherapy is the standard-of-care curative treatment for
many cancers but is associated with substantial morbidity. Concurrent chemoradiotherapy …

HPV-driven oropharyngeal cancers have significantly better survival rates than tobacco and
alcohol induced head and neck cancers. As HPV-positive patients are younger, healthier …

Radiation therapy plays an integral role in the management of head and neck cancers
(HNCs). While most HNC patients have historically been treated with photon-based …

Use of proton beam therapy has expanded, with the number of proton centres rapidly
increasing not only in the USA but also worldwide. The physical characteristics of the proton …

Importance Proton radiation therapy (PRT) has reduced radiation-induced toxic effects, such
as mucositis and xerostomia, over conventional photon radiation therapy, leading to …

In the Netherlands, the model-based approach is used to identify patients with head and
neck cancer who may benefit most from proton therapy in terms of prevention of late …

While proton radiation therapy offers substantially better dose distribution characteristics
than photon radiation therapy in certain clinical applications, data demonstrating a …

In the past 100 years, external beam energy for the treatment of cancer has continually
evolved. Two main modes have been developed. The first is radiotherapy which involves …