The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

The progression of cancers from primary tumors to invasive and metastatic stages accounts
for the overwhelming majority of cancer deaths. Understanding the molecular events which …

Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …

The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …

The eukaryotic translation initiation factor eIF4E is overexpressed in many human
malignancies where it is typically a harbinger of poor prognosis. eIF4E is positioned as a …

Protein synthesis activity is abnormally enhanced in cancer cells to support their
uncontrolled growth. However, this process needs to be tightly restricted under metabolic …

Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many
cancers, and makes fundamental contributions to carcinogenesis by stimulating the …

Recent technological advancements have shown tremendous mechanistic
accomplishments in our understanding of the mechanism of messenger RNA translation in …