Cannabinoids act at two classical cannabinoid receptors (CB1 and CB2), a 7TM orphan
receptor and the transmitter‐gated channel transient receptor potential vanilloid type‐1 …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Few and often contradictory reports exist on the long-term neurobiological consequences of
cannabinoid consumption in adolescents. The endocannabinoid system plays an important …

Cannabinoids act via cell surface G protein-coupled receptors (CB1 and CB2) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

BACKGROUND: Cannabinoid CB1 receptors (CB1Rs) mediate the effects of▵ 9-
tetrahydrocannabinol (THC), the psychoactive component in marijuana. Repeated THC …

We characterised the behavioural phenotype of mice heterozygous (O xtr+/−) for the
oxytocin receptor gene (O xtr) and compared it with that of O xtr null mice (O xtr−/−), which …

We investigated the effect of low doses of intraperitoneal Δ 9-tetrahydrocannabinol (THC) on
anxiety behavior in rats using the elevated plus maze (EPM). An anxiolytic effect was …

Enhancing the effects of endogenously-released cannabinoid ligands in the brain might
provide therapeutic effects more safely and effectively than administering drugs that act …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …