Next-generation sequencing: advances and applications in cancer diagnosis

S Serratì, S De Summa, B Pilato, D Petriella… - OncoTargets and …, 2016 - Taylor & Francis
Technological advances have led to the introduction of next-generation sequencing (NGS)
platforms in cancer investigation. NGS allows massive parallel sequencing that affords …

Electrospun nanofibers for cancer diagnosis and therapy

Z Chen, Z Chen, A Zhang, J Hu, X Wang… - Biomaterials science, 2016 - pubs.rsc.org
The advent of nanotechnology has provided unprecedented opportunities for nanomedicine.
Electrospun nanofibers have some astounding features such as high loading capacity …

Current molecular-targeted therapies in NSCLC and their mechanism of resistance

Z Schrank, G Chhabra, L Lin, T Iderzorig, C Osude… - Cancers, 2018 - mdpi.com
Lung cancer is treated with many conventional therapies, such as surgery, radiation, and
chemotherapy. However, these therapies have multiple undesirable side effects. To bypass …

[HTML][HTML] Gene mutations and actionable genetic lesions in mantle cell lymphoma

M Ahmed, L Zhang, K Nomie, L Lam, M Wang - Oncotarget, 2016 - ncbi.nlm.nih.gov
Mutations and epigenetic alterations are key events in transforming normal cells to cancer
cells. Mantle cell lymphoma (MCL), a non-Hodgkin's lymphoma of the B-cell, is an …

Glycosaminoglycans and glycolipids as potential biomarkers in lung cancer

G Li, L Li, EJ Joo, JW Son, YJ Kim, JK Kang… - Glycoconjugate …, 2017 - Springer
In this report, we used liquid chromatography-mass spectrometry and Western blotting to
analyze the content and structure of glycosaminoglycans, glycolipids and selected proteins …

Biomolecular analysis of matrix proteoglycans as biomarkers in non small cell lung cancer

MP Rangel, VK de Sá, T Prieto, JRM Martins… - Glycoconjugate …, 2018 - Springer
Matrix proteoglycans (PGs) have shown promise as biomarker in malignancies. We
employed agarose gel eletrophoresis, quantitative real-time reverse transcription …

Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature …

J Mateos, J Fafian-Labora, M Morente-Lopez… - PLoS …, 2018 - journals.plos.org
Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for
accelerated aging. Although the causal agent, a point mutation in LMNA gene, was …

KRAS and the reality of personalized medicine in non-small cell lung cancer

HO Kilgoz, G Bender, JM Scandura, A Viale… - Molecular Medicine, 2016 - Springer
Lung cancer is the leading cause of mortality among all cancer types worldwide. The latest
available global statistics of the World Health Organization report 1.59 million casualities in …

[PDF][PDF] Research progress on antioxidant activity of natural products

L Chen, X Zhang, T Hao, R Liang… - European Journal of …, 2016 - biomedicaljour.com
Natural or synthesized antioxidants are compounds that can inhibit or delay the onset
oxidation. Due to the wide availability of natural antioxidants and the increasing concerns on …

The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells

V Murray, JK Chen, MM Tanaka - Molecular biology reports, 2016 - Springer
The cancer chemotherapeutic agent, bleomycin, cleaves DNA at specific sites. For the first
time, the genome-wide DNA sequence specificity of bleomycin breakage was determined in …