Using clusterProfiler to characterize multiomics data

S Xu, E Hu, Y Cai, Z Xie, X Luo, L Zhan, W Tang… - Nature protocols, 2024 - nature.com
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …

A survey of best practices for RNA-seq data analysis

A Conesa, P Madrigal, S Tarazona, D Gomez-Cabrero… - Genome biology, 2016 - Springer
Abstract RNA-sequencing (RNA-seq) has a wide variety of applications, but no single
analysis pipeline can be used in all cases. We review all of the major steps in RNA-seq data …

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

[HTML][HTML] clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

T Wu, E Hu, S Xu, M Chen, P Guo, Z Dai, T Feng… - The innovation, 2021 - cell.com
Functional enrichment analysis is pivotal for interpreting high-throughput omics data in life
science. It is crucial for this type of tool to use the latest annotation databases for as many …

Bioaccumulation of therapeutic drugs by human gut bacteria

M Klünemann, S Andrejev, S Blasche, A Mateus… - Nature, 2021 - nature.com
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic mapping of the interactions between drugs and bacteria has only started …

Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa

G Ren, X Zhang, Y Li, K Ridout… - Science …, 2021 - science.org
Cannabis sativa has long been an important source of fiber extracted from hemp and both
medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated …

Phased diploid genome assemblies and pan-genomes provide insights into the genetic history of apple domestication

X Sun, C Jiao, H Schwaninger, CT Chao, Y Ma… - Nature …, 2020 - nature.com
Domestication of the apple was mainly driven by interspecific hybridization. In the present
study, we report the haplotype-resolved genomes of the cultivated apple (Malus domestica …

Genome assembly and genetic dissection of a prominent drought-resistant maize germplasm

T Tian, S Wang, S Yang, Z Yang, S Liu, Y Wang… - Nature Genetics, 2023 - nature.com
In the context of climate change, drought is one of the most limiting factors that influence
crop production. Maize, as a major crop, is highly vulnerable to water deficit, which causes …

Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton

Y Hu, J Chen, L Fang, Z Zhang, W Ma, Y Niu, L Ju… - Nature …, 2019 - nature.com
Allotetraploid cotton is an economically important natural-fiber-producing crop worldwide.
After polyploidization, Gossypium hirsutum L. evolved to produce a higher fiber yield and to …

Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.

J Zhang, X Zhang, H Tang, Q Zhang, X Hua, X Ma… - Nature …, 2018 - nature.com
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from
Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum …