Mitochondrial homeostasis and cellular senescence
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …
Mitochondrial ROS‐Modulated mtDNA: a potential target for cardiac aging
Y Quan, Y Xin, G Tian, J Zhou… - Oxidative medicine and …, 2020 - Wiley Online Library
Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …
Mitochondrial DNA replication in mammalian cells: overview of the pathway
M Falkenberg - Essays in biochemistry, 2018 - portlandpress.com
Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …
genome and a dedicated DNA replication machinery is required for its maintenance. Many …
Eukaryotic base excision repair: new approaches shine light on mechanism
WA Beard, JK Horton, R Prasad… - Annual review of …, 2019 - annualreviews.org
Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
Mitochondrial DNA: Epigenetics and environment
Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …
DNA damage by oxidative stress: Measurement strategies for two genomes
DNA damage is any modification to the structure of DNA that alters its coding properties
and/or interferes with cell processes. One major consequence of oxidative stress is DNA …
and/or interferes with cell processes. One major consequence of oxidative stress is DNA …
Mitochondrial DNA damage as driver of cellular outcomes
CA Nadalutti, S Ayala-Peña… - American Journal of …, 2022 - journals.physiology.org
Mitochondria are primarily involved in energy production through the process of oxidative
phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function …
phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function …
[HTML][HTML] Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …
Mitochondrial DNA‐mediated inflammation in acute kidney injury and chronic kidney disease
L Jin, B Yu, I Armando, F Han - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
The integrity and function of mitochondria are essential for normal kidney physiology.
Mitochondrial DNA (mtDNA) has been widely a concern in recent years because its …
Mitochondrial DNA (mtDNA) has been widely a concern in recent years because its …
Altered mitochondrial dynamics in motor neuron disease: an emerging perspective
M Kodavati, H Wang, ML Hegde - Cells, 2020 - mdpi.com
Mitochondria plays privotal role in diverse pathways that regulate cellular function and
survival, and have emerged as a prime focus in aging and age-associated motor neuron …
survival, and have emerged as a prime focus in aging and age-associated motor neuron …