Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …

Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

DNA damage is any modification to the structure of DNA that alters its coding properties
and/or interferes with cell processes. One major consequence of oxidative stress is DNA …

Mitochondria are primarily involved in energy production through the process of oxidative
phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function …

The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …

The integrity and function of mitochondria are essential for normal kidney physiology.
Mitochondrial DNA (mtDNA) has been widely a concern in recent years because its …

Mitochondria plays privotal role in diverse pathways that regulate cellular function and
survival, and have emerged as a prime focus in aging and age-associated motor neuron …