Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …

Granulomas, organized aggregates of immune cells, form in response to persistent stimuli
and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host …

Treatment of tuberculosis, a complex granulomatous disease, requires long-term multidrug
therapy to overcome tolerance, an epigenetic drug resistance that is widely attributed to …

During gaseous exchange the lungs are exposed to a vast variety of pathogens, allergens,
and innocuous particles. A feature of the lung immune response to lung-tropic aerosol …

The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …

Mycobacterium marinum is an opportunistic pathogen inducing infection in fresh and marine
water fish. This pathogen causes necrotizing granuloma like tuberculosis, morbidity and …

The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …