In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced changes
in chemical shift, CIS) follows changes in the chemical shifts of a protein when a ligand is …

How the epidermal growth factor receptor (EGFR) activates is incompletely understood. The
intracellular portion of the receptor is intrinsically active in solution, and to study its …

Suitable membrane mimetics are crucial to the performance of structural and functional
studies of membrane proteins. Phospholipid nanodiscs (formed when a membrane scaffold …

Misfolding of the protein α-synuclein (aS), which associates with presynaptic vesicles, has
been implicated in the molecular chain of events leading to Parkinson's disease. Here, the …

Binding events of ligands to receptors are the key for an understanding of biological
processes. Gaining insight into protein–protein and protein–ligand interactions in solution …

A comparison of HSQC and HMQC pulse schemes for recording 1H− 13C correlation maps
of protonated methyl groups in highly deuterated proteins is presented. It is shown that …

A major goal in structural biology is to unravel how molecular machines function in detail. To
that end, solution-state NMR spectroscopy is ideally suited as it is able to study biological …

The development of isotope labeling methodology has had a significant impact on NMR
studies of high-molecular-weight proteins and macromolecular complexes. Here we review …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …