Per‐and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research

SE Fenton, A Ducatman, A Boobis… - Environmental …, 2021 - Wiley Online Library
Reports of environmental and human health impacts of per‐and polyfluoroalkyl substances
(PFAS) have greatly increased in the peer‐reviewed literature. The goals of the present …

Exposure to per-and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis

E Costello, S Rock, N Stratakis, SP Eckel… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Experimental evidence indicates that exposure to certain pollutants is
associated with liver damage. Per-and polyfluoroalkyl substances (PFAS) are persistent …

Risk to human health related to the presence of perfluoroalkyl substances in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

[HTML][HTML] Exposure to a mixture of legacy, alternative, and replacement per-and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol …

K Roth, Z Yang, M Agarwal, W Liu, Z Peng… - Environment …, 2021 - Elsevier
Background Epidemiological studies have shown Per-and polyfluoroalkyl substances
(PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as …

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluorooctane sulfonic acid (PFOS) and …

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

S Fragki, H Dirven, T Fletcher… - Critical reviews in …, 2021 - Taylor & Francis
Associations between per-and polyfluoroalkyl substances (PFASs) and increased blood
lipids have been repeatedly observed in humans, but a causal relation has been debated …

Per-and polyfluorinated substances (PFASs): Environmental challenges

MP Krafft, JG Riess - Current opinion in colloid & interface science, 2015 - Elsevier
Long-chain perfluoroalkylated acids are persistent in the environment, leading to ubiquitous
exposure of biota. They have been listed as very persistent, very bioaccumulative and toxic …

Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines

J Bassler, A Ducatman, M Elliott, S Wen… - Environmental …, 2019 - Elsevier
Exposures to perfluoroalkyl substances (PFAS) including perfluoroalkyl acids (PFAAs) are
associated with increased liver enzymes in cohort studies including the C8 Health Study. In …

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

KP Das, CR Wood, MT Lin, AA Starkov, C Lau… - Toxicology, 2017 - Elsevier
Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their
extensive use in industrial and consumer products, and their slow decay. Biochemical tests …

[HTML][HTML] Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms

ME Andersen, B Hagenbuch, U Apte, JC Corton… - Toxicology, 2021 - Elsevier
Serum concentrations of cholesterol are positively correlated with exposure to
perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in humans. The …