Autophagy is an essential catabolic mechanism that delivers misfolded proteins and
damaged organelles to the lysosome for degradation. Autophagy pathways include …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
exact causes of neuronal damage are unknown, but mounting evidence indicates that …

Parkinson's disease patients report disturbed sleep patterns long before motor dysfunction.
Here, in parkin and pink1 models, we identify circadian rhythm and sleep pattern defects …

Neurodegenerative diseases are incurable diseases of the nervous system that lead to a
progressive loss of brain areas and neuronal subtypes, which is associated with an increase …

Background Most sequencing studies in Parkinson's disease (PD) have focused on either a
particular gene, primarily in familial and early onset PD samples, or on screening single …

An emerging paradigm shift for disease diagnosis is to rely on molecular characterization
beyond traditional clinical and symptom-based examinations. Although genetic alterations …

Background Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at
glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its …

Parkinson's disease (PD) is characterized by a steady loss of dopamine neurons through
apoptotic, inflammatory and oxidative stress processes. In that line of view, the pituitary …

Sphingolipids, including the basic ceramide, are a subset of bioactive lipids that consist of
many different species. Sphingolipids are indispensable for proper neuronal function, and …

Loss of the sense of smell is among the first signs of natural aging and neurodegenerative
diseases such as Alzheimer's and Parkinson's. Cellular and molecular mechanisms …