In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …

Lipids play a diverse and critical role in cellular processes in all tissues. The unique lipid
composition of nerve membranes is particularly interesting because it contains, among other …

G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …

Droplet microfluidics enables high-throughput experimentation and screening by
encapsulating chemical and biochemical samples in aqueous droplets segmented by an …

Amphiphilic copolymers capable of extracting membrane proteins directly from lipid bilayers
into" native nanodiscs" promise a simpler membrane protein sample preparation procedure …

Cholesterol in GPCR Structures: Prevalence and Relevance | The Journal of Membrane
Biology Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Lipid nanodiscs are small synthetic lipid bilayer structures that are stabilized in solution by
special circumscribing (or scaffolding) proteins or polymers. Because they create native-like …

Lipid nanodiscs are macromolecular assemblies, where a scaffold protein is wrapped
around a nanosized disc of a lipid bilayer, thus protecting the hydrocarbon chains at the disc …

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …