Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

To summarize current knowledge regarding mechanisms of radiation-induced normal tissue
injury and medical countermeasures available to reduce its severity. Advances in radiation …

Successful hematopoietic stem cell transplant requires the infusion of a sufficient number of
hematopoietic stem/progenitor cells (HSPCs) that are capable of homing to the bone marrow …

Rationale: The impact of diabetes mellitus on bone marrow (BM) structure is incompletely
understood. Objective: Investigate the effect of type-2 diabetes mellitus (T2DM) on BM …

MicroRNAs (miRNAs) are important regulators of gene expression and fundamentally
impact on cardiovascular function in health and disease. A tight control of miRNA expression …

Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral
drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 …

AMD3100 was recently FDA-approved for stem cell mobilization in combination with
granulocyte-colony stimulating factor in patients with non-Hodgkin's lymphoma and multiple …

Bone marrow (BM) aspirates, mobilized peripheral blood, and umbilical cord blood (UCB)
have developed as graft sources for hematopoietic stem and progenitor cells (HSPCs) for …

AMD3100 was originally discovered as an anti-HIV agent effective in inhibiting the
replication of HIV in vitro at nanomolar concentrations. We found it to be a potent and …