Infertility in men: advances towards a comprehensive and integrative strategy for precision theranostics

M Assidi - Cells, 2022 - mdpi.com
Male infertility is an increasing and serious medical concern, though the mechanism
remains poorly understood. Impaired male reproductive function affects approximately half …

Sperm telomere length as a novel biomarker of male infertility and embryonic development: A systematic review and meta-analysis

Y Yuan, Y Tan, X Qiu, H Luo, Y Li, R Li… - Frontiers in …, 2023 - frontiersin.org
Background Telomeres have an essential role in maintaining the integrity and stability of the
human chromosomal genome and preserving essential DNA biological functions. Several …

Oxidative stress and reproductive function: Sperm telomeres, oxidative stress, and infertility

A Moazamian, P Gharagozloo, RJ Aitken… - …, 2022 - rep.bioscientifica.com
In brief Oxidative stress is recognized as an underlying driving factor of both telomere
dysfunction and human subfertility/infertility. This review briefly reassesses telomere integrity …

Telomere length, a new biomarker of male (in) fertility? A systematic review of the literature

AJ Fattet, M Chaillot, I Koscinski - Genes, 2023 - mdpi.com
Male factors are suspected in around half cases of infertility, of which up to 40% are
diagnosed as idiopathic. In the context of a continuously increased resort to ART and …

Male obesity is associated with sperm telomere shortening and aberrant mRNA expression of autophagy-related genes

P Raee, Z Shams Mofarahe, H Nazarian… - Basic and Clinical …, 2023 - Springer
Background Obesity is regarded a global public health crisis. It has been implicated in a
variety of health problems, but when it comes to male fertility, how and to what extent obesity …

The impact of lifestyle on sperm function, telomere length, and IVF outcomes

M Sharqawi, S Hantisteanu, A Bilgory… - American Journal of …, 2022 - journals.sagepub.com
Many risk factors can potentially influence sperm quality. Telomeres confer stability on the
chromosome and their dysfunction has been implicated in conditions such as cancer, aging …

Reproductive aging and telomeres: Are women and men equally affected?

L Chico-Sordo, I Cordova-Oriz, AM Polonio… - Mechanisms of Ageing …, 2021 - Elsevier
Successful reproduction is very important for individuals and for society. Currently, the
human health span and lifespan are the object of intense and productive investigation with …

A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs

M Giaccherini, M Gentiluomo, PG Arcidiacono… - …, 2022 - academic.oup.com
Intraductal papillary mucinous neoplasms (IPMNs) are nonobligatory precursor lesions of
pancreatic ductal adenocarcinoma (PDAC). The identification of molecular biomarkers able …

Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies

M Fernández de la Puente, A Salas‐Huetos… - …, 2024 - Wiley Online Library
Background Telomeres are essential for the integrity of chromosome ends during cell
division and their involvement in different processes linked to aging has been established …

Serum testosterone and sex hormone–binding globulin are inversely associated with leucocyte telomere length in men: a cross-sectional analysis of the UK Biobank …

RJ Marriott, K Murray, CA Budgeon… - European journal of …, 2023 - academic.oup.com
Objective Older men on an average have lower testosterone concentrations, compared with
younger men, and more age-related comorbidities. Whether lower testosterone …