The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …

The claustrum, a subcortical nucleus forming extensive connections with the neocortex, has
been implicated in sensory selection. Sensory-evoked claustrum activity is thought to …

The synthetic opioid fentanyl is a major contributor to the current opioid addiction crisis. We
report that claustral neurons projecting to the frontal cortex limit oral fentanyl self …

Neural activity in the claustrum has been associated with a range of vigilance states, yet the
activity patterns and efficacy of synaptic communication of identified claustrum neurons have …

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and
subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse …

The claustrum is a small subcortical structure with widespread connections to disparate
regions of the cortex. However, the impact of the claustrum on cortical activity is not fully …

The anterior cingulate cortex (ACC) is critical for the perception and unpleasantness of pain.
1, 2, 3, 4, 5, 6 It receives nociceptive information from regions such as the thalamus and …

The claustrum is highly interconnected with many structures in the brain, but the organizing
principles governing its vast connectivity have yet to be fully explored. We investigated the …

The claustrum coordinates the activities of individual cortical areas through abundant
reciprocal connections with the cerebral cortex. Although these excitatory connections have …

Animals are known to exhibit innate and learned forms of defensive behaviors, but it is
unclear whether animals can escape through methods other than these forms. In this study …