Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of
inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the …

Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …

Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …