In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

The host response to biomaterials has been studied for decades. Largely, the interaction of
host immune cells, macrophages in particular, with implanted materials has been …

Recent discoveries reveal complex interactions between skeletal muscle and the immune
system that regulate muscle regeneration. In this review, we evaluate evidence that …

Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

A transient increase in local pro-inflammatory cytokine expression following skeletal muscle
injury mediates the repair and regeneration of damaged myofibers through myogenesis …

Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can
result in ultrastructural muscle disruption, impaired excitation–contraction coupling …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Skeletal muscle has a robust capacity for regeneration following injury. However, few if any
effective therapeutic options for volumetric muscle loss are available. Autologous muscle …

Satellite cells are dormant progenitors located at the periphery of skeletal myofibers that can
be triggered to proliferate for both self-renewal and differentiation into myogenic cells. In …

Although p38 MAPK activation is essential for myogenesis, the upstream signaling
mechanism that activates p38 during myogenesis remains undefined. We recently reported …