Precision medicine has the potential to have a significant impact on both drug development
and patient care. It is crucial to not only provide prompt effective antiseizure treatment for …

There are 2 major categories of patients with seizures and chronic kidney disease (CKD):
patients who develop acute symptomatic seizures in the setting of CKD and patients with …

Background Therapeutic drug monitoring (TDM) is recommended during valproic acid (VPA)
use, and total serum concentration has been widely adopted. However, the free form of VPA …

Continuous RRT (CRRT) is the preferred dialysis modality for solute management, acid-
base stability, and volume control in patients who are critically ill with AKI in the intensive …

Introduction Levetiracetam (LEV) is one of the most widely used anti-seizure medications
(ASMs) in clinical practice. This is due both to a different mechanism of action when …

Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a
common complication in critical illness and has a significant impact on pharmacokinetic …

Limited data exist on the effect of continuous renal replacement therapy (CRRT) methods on
anti‐epileptic drug pharmacokinetics (PK). This prospective practice‐based PK study aims to …

Introduction: Status epilepticus (SE) is a neurologic and medical emergency with significant
related morbidity and mortality. Hepatic or renal dysfunction can considerably affect the …

Background Lacosamide is one of the anticonvulsants used in critically ill patients. This
study aimed to suggest appropriate lacosamide dosing regimens in critically ill patients …

Abstract SINGU, Bonifasius S.; MORRISON, Helen; IRENGEYA, Lydia and VERBEECK,
Roger K.. Therapeutic drug monitoring of phenytoin and valproic acid in critically ill patients …