[HTML][HTML] Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
T cell metabolism in infection
JA Wik, BS Skålhegg - Frontiers in immunology, 2022 - frontiersin.org
T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication
Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a
virus-induced inflammatory disease of the airways and lungs that leads to severe multi …
virus-induced inflammatory disease of the airways and lungs that leads to severe multi …
Innate metabolic responses against viral infections
CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …
disease. At the systemic level, a significant feature of viral infection and inflammation that …
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells
Y Gong, N Tang, P Liu, Y Sun, S Lu, W Liu, L Tan… - Autophagy, 2022 - Taylor & Francis
Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …
Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity
There is an urgent need to identify which COVID-19 patients will develop life-threatening
illness so that medical resources can be optimally allocated and rapid treatment can be …
illness so that medical resources can be optimally allocated and rapid treatment can be …
Coronavirus infection and cholesterol metabolism
J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …
insatiable need to replicate while evading the host immune system. These similarities …
Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: A comprehensive evidential insight
SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …