The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its
clinical features are the proliferation of joint synovial tissue, the formation of pannus and the …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

The balance between immune effector cells and immunosuppressive cells and how this
regulates the tumor microenvironment has been well described. A significant contribution of …

Regulatory B (Breg) cells are immunosuppressive cells that support immunological
tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth …

Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

Success with B cell depletion using rituximab has proven the concept that B lineage cells
represent a valid target for the treatment of autoimmune diseases, and has promoted the …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Tumorigenesis proceeds through discrete steps where acquisition of genetic lesions and
changes in the surrounding microenvironment combine to drive unrestricted neoplastic …