The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …

Thousands of somatic mutations accrue in most human cancers, and their causes are
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …

The development of high-affinity B cell memory is regulated through three separable
phases, each involving antigen recognition by specific B cells and cognate T helper cells …

Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR)
and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting …

Activation-induced cytidine deaminase (AID) initiates antibody gene diversification by
creating U: G mismatches. However, AID is not specific for antibody genes; Off-target lesions …

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …