Anti-trypanosomatid drug discovery: progress and challenges
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
Applications of bioluminescence in biotechnology and beyond
AJ Syed, JC Anderson - Chemical Society Reviews, 2021 - pubs.rsc.org
Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity
B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
FJ Sánchez-Valdéz, A Padilla, W Wang, D Orr… - Elife, 2018 - elifesciences.org
The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo
exposure to highly effective trypanocidal compounds prompted us to explore the potential for …
exposure to highly effective trypanocidal compounds prompted us to explore the potential for …
Pathology and pathogenesis of Chagas heart disease
KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
Chagas disease drug discovery: toward a new era
E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease
Z Liu, R Ulrich vonBargen, AL Kendricks… - Nature …, 2023 - nature.com
Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …
Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …