Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Genome-wide association studies have identified risk loci linked to inflammatory bowel
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …