Nickel: Human health and environmental toxicology

G Genchi, A Carocci, G Lauria, MS Sinicropi… - International journal of …, 2020 - mdpi.com
Nickel is a transition element extensively distributed in the environment, air, water, and soil.
It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous …

Nickel (Ni) phytotoxicity and detoxification mechanisms: A review

A Mustafa, U Zulfiqar, MZ Mumtaz, M Radziemska… - Chemosphere, 2023 - Elsevier
Scientists studying the environment, physiology, and biology have been particularly
interested in nickel (Ni) because of its dual effects (essentiality and toxicity) on terrestrial …

Nickel in terrestrial biota: Comprehensive review on contamination, toxicity, tolerance and its remediation approaches

A Kumar, DK Jigyasu, G Subrahmanyam, R Mondal… - Chemosphere, 2021 - Elsevier
Nickel (Ni) has been a subject of interest for environmental, physiological, biological
scientists due to its dual effect (toxicity and essentiality) in terrestrial biota. In general, the …

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

L Yao, F Conforti, C Hill, J Bell, L Drawater… - Cell Death & …, 2019 - nature.com
The contribution of epithelial–mesenchymal transition (EMT) to human lung fibrogenesis is
controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar …

Epithelial-mesenchymal transition: Insights into nickel-induced lung diseases

HW Lee, CC Jose, S Cuddapah - Seminars in cancer biology, 2021 - Elsevier
Nickel compounds are environmental toxicants, prevalent in the atmosphere due to their
widespread use in several industrial processes, extensive consumption of nickel containing …

Epigenetic regulation in chromium-, nickel-and cadmium-induced carcinogenesis

L Zhao, R Islam, Y Wang, X Zhang, LZ Liu - Cancers, 2022 - mdpi.com
Simple Summary Environmental and occupational exposure to heavy metals are risk factors
for cancers. However, the molecular mechanisms of how heavy metals induce …

Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis

Z Wang, C Yang - Seminars in cancer biology, 2019 - Elsevier
Arsenic, cadmium, nickel and hexavalent chromium are among the most common
environmental pollutants and potent carcinogens. Chronic exposure to these metals causes …

Zinc finger domains as therapeutic targets for metal-based compounds–an update

C Abbehausen - Metallomics, 2019 - academic.oup.com
Zinc finger proteins are one of the most abundant families of proteins and present a wide
range of structures and functions. The structural zinc ion provides the correct conformation to …

ZEB1: New advances in fibrosis and cancer

L Cheng, MY Zhou, YJ Gu, L Chen, Y Wang - Molecular and Cellular …, 2021 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1) is an important transcription factor in epithelial
mesenchymal transition (EMT) which participates in the numerous life processes, such as …

Quantification and mapping of alkylation in the human genome reveal single nucleotide resolution precursors of mutational signatures

Y Jiang, C Mingard, SM Huber, V Takhaveev… - ACS Central …, 2023 - ACS Publications
Chemical modifications to DNA bases, including DNA adducts arising from reactions with
electrophilic chemicals, are well-known to impact cell growth, miscode during replication …