ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields
such as medicine, agriculture, and environmental science. Understanding its complexity and …

Ethnopharmacological relevance Natural products play a critical role in drug development
and is emerging as a potential source of biologically active metabolites for therapeutic …

Metastatic clear cell renal cell carcinoma has heterogenous tumor microenvironment (TME).
Among the metastatic lesions, pancreas metastasis is rare and controversy in treatment …

Traditional Chinese medicine has been used in China for thousands of years. In 2022, the
14th Five-Year Plan for the Development of Traditional Chinese Medicine was released …

Pancreatic cancer, characterized by its poor prognosis, exhibits a marked resistance to
conventional chemotherapy and immunotherapy, underscoring the urgent need for more …

Gynecologic cancers can make up the bulk of cancers in both humans and animals. The
stage of diagnosis and the type of tumor, its origin, and its spread are a few of the factors that …

The ongoing COVID-19 pandemic is a persistent challenge, with continued breakthrough
infections despite vaccination efforts. This has spurred interest in alternative preventive …

Abstract Anti-CDK4/6 therapy has been employed for the treatment for head and neck
squamous cell carcinoma (HNSCC) with CDK4/6 hyperactivation, but the response rate is …

Abstract The Staphylococcal nuclease and Tudor domain containing 1 (SND1) has been
identified as an oncoprotein. Our previous study demonstrated that SND1 impedes the major …