Indoles—A promising scaffold for drug development
TV Sravanthi, SL Manju - European Journal of Pharmaceutical Sciences, 2016 - Elsevier
Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …
Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
The importance of indole and azaindole scaffold in the development of antitumor agents
Y Han, W Dong, Q Guo, X Li, L Huang - European journal of medicinal …, 2020 - Elsevier
With some indoles and azaindoles being successfully developed as anticancer drugs, the
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …
[HTML][HTML] A comprehensive review on biological activities of oxazole derivatives
S Kakkar, B Narasimhan - BMC chemistry, 2019 - Springer
The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal
chemistry have been increased in the past few years. Oxazole is an important heterocyclic …
chemistry have been increased in the past few years. Oxazole is an important heterocyclic …
Synthesis and anticancer activity of 5-(3-indolyl)-1, 3, 4-thiadiazoles
A series of 5-(3-indolyl)-2-substituted-1, 3, 4-thiadiazoles 5a–m were synthesized and their
cytotoxicity analyzed against six human cancer cell lines. The reaction of indole-3-carboxylic …
cytotoxicity analyzed against six human cancer cell lines. The reaction of indole-3-carboxylic …
[HTML][HTML] Benzoxazole derivatives: design, synthesis and biological evaluation
Background A new series of benzoxazole analogues was synthesized and checked for their
in vitro antibacterial, antifungal and anticancer activities. Results and discussion The …
in vitro antibacterial, antifungal and anticancer activities. Results and discussion The …
Synthesis, antiproliferative and apoptosis induction potential activities of novel bis (indolyl) hydrazide-hydrazone derivatives
In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …
inhibition and apoptosis induction characteristics are being strongly screened for their …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Electrochemical synthesis of oxazoles via a phosphine-mediated deoxygenative [3+ 2] cycloaddition of carboxylic acids
X Zhang, Q Yuan, H Zhang, ZJ Shen, L Zhao… - Green …, 2023 - pubs.rsc.org
A direct electrochemical phosphine-mediated deoxygenative [3+ 2] cycloaddition strategy for
oxazole synthesis is described, employing naturally abundant and inexpensive carboxylic …
oxazole synthesis is described, employing naturally abundant and inexpensive carboxylic …
Novel bis (indolyl) hydrazide–hydrazones as potent cytotoxic agents
A series of bis (indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for
their cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …
their cytotoxicity against selected human cancer cell lines. The reaction of indole-3 …