Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Background ADH1B rs1229984 and ALDH2 rs671 are the specifically prevalent functional
variants in the East Asians. These variants, which result in a dramatic change in enzyme …

Alcohol use disorder (AUD) is a prominent contributor to global morbidity and mortality. Its
complex etiology involves genetics, epigenetics, and environmental factors. We review …

Alcohol use disorder (AUD) is a leading cause of death and disability worldwide. Genome-
wide association studies (GWAS) have identified~ 30 AUD risk genes in European …

Abstract Purpose Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol
use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the …

Abstract Background/Aim: Alcohol use disorder (AUD) is a chronic, multifactorial psychiatric
condition with an enormous impact on public health and social cost. Genetic studies suggest …

Purpose To estimate the burden of alcohol-attributable cancer in East Asian populations
accounting for aldehyde dehydrogenase-2 (ALDH2) genotype-specific cancer risk and …

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are two major alcohol-
metabolizing enzymes. Moderate alcohol intake is a protective modified factor in Alzheimer's …

Background and aims Genomic and transcriptomic findings greatly broaden the biological
knowledge regarding substance use. However, systematic convergence and comparison …