Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation

TH Tran, A Heinold, M Spackova, L Pham… - Best Practice & …, 2024 - Elsevier
Advances in hematopoietic cell transplantation have expanded the use of alternative donors
such as haploidentical family donors or mismatched unrelated donors. However, donor …

Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect

K Umino, K Morita, T Ikeda, S Kawaguchi, T Nagayama… - Blood, 2023 - ashpublications.org
Chronic graft-versus-host disease (cGVHD) is a multiorgan syndrome with clinical features
resembling those of autoimmune diseases. Thus, understanding commonalities in the …

Desensitization Strategies for Donor-Specific Antibodies in HLA-Mismatched Stem Cell Transplantation Recipients: What We Know and What We Do Not Know

Y Zhou, YL Chen, XY Huang, YJ Chang - Oncology and Therapy, 2024 - Springer
In human leukocyte antigen (HLA)-mismatched allogeneic stem cell transplantation settings,
donor-specific anti-HLA antibodies (DSAs) can independently lead to graft failure, including …

[HTML][HTML] Incidence and role of recipient-specific antibodies in allogeneic hematopoietic cell transplantation from mismatched related donors

A Sadowska-Klasa, A Dukat-Mazurek… - … and Cellular Therapy, 2024 - Elsevier
High titer of donor-specific antibodies (DSAs) increases the risk of graft rejection after
mismatched related hematopoietic cell transplantation (HCT). There are no data regarding …

[HTML][HTML] High-Dose immunoglobulin Intervention as an effective and simple strategy for donor specific Anti-HLA antibody desensitization in haploidentical transplant

J Zhu, Q Wang, Y Liu, Y Dong, Z Liang, Y Yin… - International …, 2023 - Elsevier
Donor-specific anti-HLA antibody (DSA) is a significant obstacle to successful haploidentical
hematopoietic stem cell transplantation (haplo-HSCT) and is associated with poor …

Applying Rituximab During the Conditioning Regimen Prevents Epstein–Barr Virus Infection Following Allogeneic Hematopoietic Stem Cell Transplant in a Children's …

Y Ruan, L Chen, T Luo, D Xie, W Cao, X Liu… - Infectious Diseases and …, 2023 - Springer
Introduction Since hematopoietic stem cell transplant (HSCT) is an important therapy for
malignant and non-malignant pediatric diseases, improving transplant-related mortality …

Uniform Graft-versus-Host Disease Prophylaxis using Post-Transplantation Cyclophosphamide, Methotrexate, and Cyclosporine following Peripheral Blood …

S Gong, X Tian, R Yang, L Yang, Z Wang… - … and Cellular Therapy, 2024 - Elsevier
Although the survival of patients with transfusion-dependent thalassemia (TD-TM) is
reportedly inferior after haploidentical hematopoietic stem cell transplantation (HSCT), the …

[HTML][HTML] Treatment with the combination of Rituximab and intravenous γ globulin is effective in promoting engraftment in donor-specific antibody positive patients …

Y Shen, L Zhang, X Zhang, T Zhang, E Jiang… - … and cellular therapy, 2023 - Elsevier
Donor-specific anti-HLA antibodies (DSAs) are a major cause of engraftment failure in
patients receiving haploidentical stem cell transplantation (HaploSCT). Effective procedures …

The use of haploidentical stem cell transplant as an alternative donor source in patients with decreased access to matched unrelated donors

C Graham, M Litzow - Hematology, 2024 - Taylor & Francis
Introduction The likelihood of finding HLA-matched unrelated donors for rare HLA types and
non-white European ancestry continues to be a challenge with less than a 70% chance of …

HLA diversity in ethnic populations can affect detection of donor-specific antibodies by single antigen beads

JC Quon, K Kaneta, N Fotiadis, J Menteer… - Frontiers in …, 2023 - frontiersin.org
Introduction In solid-organ transplantation, human leukocyte antigen (HLA) donor-specific
antibodies (DSA) are strongly associated with graft rejection, graft loss, and patient death …