Phosphorylation offers a dynamic way to regulate protein activity and subcellular
localization, which is achieved through its reversibility and fast kinetics. Adding or removing …

Regulation of gene expression is central to many biological processes. Although
reconstruction of regulatory circuits from genomic data alone is therefore desirable, this …

Dynamic morphological changes of intracellular organelles are often regulated by protein
phosphorylation or dephosphorylation,,,,–. Phosphorylation modulates stereospecific …

Phosphorylation is a critical post-translational modification involved in the regulation of
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …

Living organisms have evolved protein phosphorylation, a rapid and versatile mechanism
that drives signaling and regulates protein function. We report the phosphoproteomes of 18 …

Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease.
Kinase target recognition at the active site is in part determined by a few amino acids around …

Protein kinases are essential for signal transduction and control of most cellular processes,
including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of …

One of the last uncharted territories in evolutionary biology concerns the link with cell
biology. Because all phenotypes ultimately derive from events at the cellular level, this …

Highlights•Small proteins play big roles in cell biology.•Small proteins are underrepresented
in proteomics datasets because of experimental and observational biases.•Ribosome …

FPR1, FPR2, and FPR3 are members of Formyl Peptides Receptors (FPRs) family
belonging to the GPCR superfamily. FPR2 is a low affinity receptor for formyl peptides and it …