The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Hypoxia, a common factor ruling the microenvironment composition, leads to tumor
progression. In this hypoxic context, cytokines and cells cooperate to favor cancer …

Dacarbazine (DTIC) dominates chemotherapy for malignant melanoma (MM). However, the
hydrophobicity, photosensitivity, instability, and toxicity to normal cells of DTIC limit its …

Tumour microenvironment determines the fate of treatments. Reconstitution of tumour
conditions is mandatory for alternative in vitro methods devoted to cancer development and …

The current study aimed to explore the role of tumor-derived extracellular vesicles (EVs) in
angiogenesis during nasopharyngeal carcinoma (NPC). NPC biopsy specimens were …

Endothelial cells (ECs) lining the blood vessels are important players in many biological
phenomena but are crucial in hypoxia-dependent diseases where their deregulation …

Simple Summary Melanoma is the most aggressive and potentially lethal form of skin
cancer. Research over recent decades has highlighted the role of tumour vasculature in …

Hypoxia characterizes growing tumors and contributes significantly to their aggressiveness.
Hypoxia-inducible factors (HIFs 1 and 2) are stabilized and act differentially as transcription …

Pathologic angiogenesis directly responds to tumour hypoxia and controls the
molecular/cellular composition of the tumour microenvironment, increasing both immune …