Advances in multicellular spheroids formation
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
Promising applications of tumor spheroids and organoids for personalized medicine
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
M Vinci, S Gowan, F Boxall, L Patterson… - BMC biology, 2012 - Springer
Background There is overwhelming evidence that in vitro three-dimensional tumor cell
cultures more accurately reflect the complex in vivo microenvironment than simple two …
cultures more accurately reflect the complex in vivo microenvironment than simple two …
Three-dimensional in vitro tumor models for cancer research and drug evaluation
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …
Generation of multicellular tumor spheroids with microwell-based agarose scaffolds for drug testing
X Gong, C Lin, J Cheng, J Su, H Zhao, T Liu, X Wen… - PloS one, 2015 - journals.plos.org
Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …
Organ-on-a-chip platforms for studying drug delivery systems
Novel microfluidic tools allow new ways to manufacture and test drug delivery systems.
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines
G Lazzari, P Couvreur, S Mura - Polymer Chemistry, 2017 - pubs.rsc.org
The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …
Comparative analysis of 3D bladder tumor spheroids obtained by forced floating and hanging drop methods for drug screening
RLF Amaral, M Miranda, PD Marcato… - Frontiers in …, 2017 - frontiersin.org
Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the
antitumor activity of compounds more accurately, since these models reproduce the tumor …
antitumor activity of compounds more accurately, since these models reproduce the tumor …
Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres
DP Ivanov, TL Parker, DA Walker, C Alexander… - PloS one, 2014 - journals.plos.org
Three-dimensional cell culture has many advantages over monolayer cultures, and
spheroids have been hailed as the best current representation of small avascular tumours in …
spheroids have been hailed as the best current representation of small avascular tumours in …
Microfluidic trends in drug screening and drug delivery
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
cost of bringing a drug from concept to market emphasizes the need for new approaches to …