Structural modification aimed for improving solubility of lead compounds in early phase drug discovery
Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …
Oral delivery of hydrophobic flavonoids and their incorporation into functional foods: Opportunities and challenges
Flavonoids have long been known for their healing powers in human ailments, with recent
trends seeing these natural bioactive components increasingly extended into nutraceuticals …
trends seeing these natural bioactive components increasingly extended into nutraceuticals …
Formulation and optimization of naringin loaded nanostructured lipid carriers using Box-Behnken based design: In vitro and ex vivo evaluation
Naringin (NAR) is a highly abundant flavonoid found in plants. Grapefruit, citrus fruit,
oregano, and tomatoes all seem to be NAR-rich foods [1]. Numerous studies have …
oregano, and tomatoes all seem to be NAR-rich foods [1]. Numerous studies have …
Experimental and computational approaches for solubility measurement of pyridazinone derivative in binary (DMSO+ water) systems
The current research work was performed to evaluate the solubilization behavior, solution
thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative ie, 6 …
thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative ie, 6 …
Measurement of naringin from citrus fruits by high-performance liquid chromatography–A review
Naringin is a flavonoid found primarily in citrus species with especially high concentrations
being present in grapefruit (Citrus paradisi), bitter orange (Citrus aurantium), and pomelo …
being present in grapefruit (Citrus paradisi), bitter orange (Citrus aurantium), and pomelo …
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage
X Li, Y Lu, Y Wang, S Zhou, L Li, F Zhao - Drug Delivery, 2021 - Taylor & Francis
In the human body, joint cartilage is of great importance. It has long been a big therapeutic
problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories …
problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories …
Optimized freeze-dried solid-dispersions boost naringin solubility, antibacterial and in-vitro anticancer activity
SA Alanazi, SS Imam, S Alshehri, MM Alanazi… - Journal of Drug Delivery …, 2024 - Elsevier
Naringin (NRG) is a water insoluble glycoside having wide range of therapeutic efficacy. Its
efficacy is limited due to its poor water solubility and bioavailability. In the current research …
efficacy is limited due to its poor water solubility and bioavailability. In the current research …
Solubility and dissolution thermodynamics of 5-fluorouracil in (ethanol+ water) mixtures
Equilibrium mole fraction solubility of 5-fluorouracil (5-FU) in 19 aqueous-ethanolic mixtures,
as well as in neat water and neat ethanol, was determined at seven temperatures from …
as well as in neat water and neat ethanol, was determined at seven temperatures from …
Methods for estimating supersaturation in antisolvent crystallization systems
JM Schall, G Capellades, AS Myerson - CrystEngComm, 2019 - pubs.rsc.org
The mole fraction and activity coefficient-dependent (MFAD) supersaturation expression is
the least-assumptive, practical choice for calculating supersaturation in solvent mixtures …
the least-assumptive, practical choice for calculating supersaturation in solvent mixtures …
Screening β-glucosidase and α-rhamnosidase for biotransformation of naringin to naringenin by the one-pot enzymatic cascade
M Lu, S Liu, L Zhao, J Pei - Enzyme and Microbial Technology, 2023 - Elsevier
Naringenin is a kind of flavonoid with many kinds of pharmacological activities, and is also a
key intermediate metabolite in the flavonoid synthesis pathway. In this study, three α …
key intermediate metabolite in the flavonoid synthesis pathway. In this study, three α …