Structural modification aimed for improving solubility of lead compounds in early phase drug discovery

B Das, ATK Baidya, AT Mathew, AK Yadav… - Bioorganic & Medicinal …, 2022 - Elsevier
Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

Oral delivery of hydrophobic flavonoids and their incorporation into functional foods: Opportunities and challenges

R Premathilaka, A Rashidinejad, M Golding, J Singh - Food Hydrocolloids, 2022 - Elsevier
Flavonoids have long been known for their healing powers in human ailments, with recent
trends seeing these natural bioactive components increasingly extended into nutraceuticals …

Formulation and optimization of naringin loaded nanostructured lipid carriers using Box-Behnken based design: In vitro and ex vivo evaluation

A Alhalmi, S Amin, S Beg, R Al-Salahi, SR Mir… - Journal of Drug Delivery …, 2022 - Elsevier
Naringin (NAR) is a highly abundant flavonoid found in plants. Grapefruit, citrus fruit,
oregano, and tomatoes all seem to be NAR-rich foods [1]. Numerous studies have …

Experimental and computational approaches for solubility measurement of pyridazinone derivative in binary (DMSO+ water) systems

F Shakeel, S Alshehri, M Imran, N Haq, A Alanazi… - Molecules, 2019 - mdpi.com
The current research work was performed to evaluate the solubilization behavior, solution
thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative ie, 6 …

Measurement of naringin from citrus fruits by high-performance liquid chromatography–A review

A Csuti, B Sik, Z Ajtony - Critical Reviews in Analytical Chemistry, 2024 - Taylor & Francis
Naringin is a flavonoid found primarily in citrus species with especially high concentrations
being present in grapefruit (Citrus paradisi), bitter orange (Citrus aurantium), and pomelo …

Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage

X Li, Y Lu, Y Wang, S Zhou, L Li, F Zhao - Drug Delivery, 2021 - Taylor & Francis
In the human body, joint cartilage is of great importance. It has long been a big therapeutic
problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories …

Optimized freeze-dried solid-dispersions boost naringin solubility, antibacterial and in-vitro anticancer activity

SA Alanazi, SS Imam, S Alshehri, MM Alanazi… - Journal of Drug Delivery …, 2024 - Elsevier
Naringin (NRG) is a water insoluble glycoside having wide range of therapeutic efficacy. Its
efficacy is limited due to its poor water solubility and bioavailability. In the current research …

Solubility and dissolution thermodynamics of 5-fluorouracil in (ethanol+ water) mixtures

S Akay, B Kayan, A Jouyban, F Martínez - Journal of Molecular Liquids, 2021 - Elsevier
Equilibrium mole fraction solubility of 5-fluorouracil (5-FU) in 19 aqueous-ethanolic mixtures,
as well as in neat water and neat ethanol, was determined at seven temperatures from …

Methods for estimating supersaturation in antisolvent crystallization systems

JM Schall, G Capellades, AS Myerson - CrystEngComm, 2019 - pubs.rsc.org
The mole fraction and activity coefficient-dependent (MFAD) supersaturation expression is
the least-assumptive, practical choice for calculating supersaturation in solvent mixtures …

Screening β-glucosidase and α-rhamnosidase for biotransformation of naringin to naringenin by the one-pot enzymatic cascade

M Lu, S Liu, L Zhao, J Pei - Enzyme and Microbial Technology, 2023 - Elsevier
Naringenin is a kind of flavonoid with many kinds of pharmacological activities, and is also a
key intermediate metabolite in the flavonoid synthesis pathway. In this study, three α …