The synthetic and therapeutic expedition of isoxazole and its analogs

N Agrawal, P Mishra - Medicinal Chemistry Research, 2018 - Springer
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Recent progress in the synthesis of isoxazoles

DX Duc, VC Dung - Current Organic Chemistry, 2021 - ingentaconnect.com
Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one
oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad …

Preparation of 3, 5-disubstituted pyrazoles and isoxazoles from terminal alkynes, aldehydes, hydrazines, and hydroxylamine

R Harigae, K Moriyama, H Togo - The Journal of organic …, 2014 - ACS Publications
The reaction of terminal alkynes with n-BuLi, and then with aldehydes, followed by the
treatment with molecular iodine, and subsequently hydrazines or hydroxylamine provided …

Multicomponent reactions: a sustainable tool to 1, 2-and 1, 3-azoles

KN Singh - Organic & Biomolecular Chemistry, 2018 - pubs.rsc.org
Multicomponent reactions (MCRs) have emerged as an efficient and eco-safe approach in
organic synthesis. The influential nature of this approach has been well established in the …

A study on synthesis of chalcone derived-5-membered isoxazoline and isoxazole scaffolds

S Bhardwaj, A Bendi, L Singh - Current Organic Synthesis, 2022 - ingentaconnect.com
Chalcone-derived isoxazole scaffolds remain the central focus due to their greater
biological, clinical, and pharmacological properties. The present study reviews the synthesis …

Visible-Light-Mediated Synthesis of 1, 2, 4-Dithiazolidines from β-Ketothioamides through a Hydrogen-Atom-Transfer Photocatalytic Approach of Eosin Y

MA Ansari, D Yadav, S Soni, A Srivastava… - The Journal of …, 2019 - ACS Publications
An efficient protocol for visible-light-mediated synthesis of a specific class of 1, 2, 4-
dithiazolidines from β-ketothioamides is devised employing eosin Y as a photoinitiator at …

Metal-and Catalyst-Free, Formal [4+ 1] Annulation via Tandem C O/C S Functionalization: One-Pot Access to 3, 5-Disubstituted/Annulated Isothiazoles

G Shukla, A Srivastava, MS Singh - Organic letters, 2016 - ACS Publications
An operationally simple and user-friendly new protocol for the synthesis of 3, 5-disubstituted/
annulated isothiazoles is devised utilizing β-ketodithioesters/β-ketothioamides and NH4OAc …

Facile, capable, atom-economical one-pot multicomponent strategy for the direct regioselective synthesis of novel isoxazolo[5,4-d]pyrimidines

M Rimaz, H Mousavi, L Ozzar, B Khalili - Research on Chemical …, 2019 - Springer
Facile and efficient NaOH-promoted one-pot regioselective synthesis of 5, 7-dimethyl-3-
(arylamino) isoxazolo [5, 4-d] pyrimidine-4, 6 (5 H, 7 H)-diones and 5, 7-dimethyl-3 …

Synthetic applications and computational perspectives on eosin Y induced direct HAT process

J Inoa, G Dominici, R Eldabagh, JJ Foley IV, Y Xing - Synthesis, 2021 - thieme-connect.com
In recent years, advancements in photocatalysis have allowed for a plethora of chemical
transformations under milder conditions. Many of these photochemical reactions utilize …

General Platform for the Conversion of Isoxazol‐5‐ones to 3, 5‐Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross‐Coupling …

AAG Fernandes, AF da Silva… - European Journal of …, 2019 - Wiley Online Library
A general platform for the conversion of isoxazol‐5‐ones to 3, 5‐disubstituted isoxazoles
has been developed via a two‐step strategy. The first step leads to the formation of 5 …