Antibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)

L Zhou, Y Deng, Y Ren, HL Poon, WY Chu… - Chemical Engineering …, 2024 - Elsevier
Bacterial keratitis (BK), which accounts for over 50% of the reported cases of microbial
keratitis, is a condition that can result in vision loss and blindness if left untreated. Antibiotics …

[HTML][HTML] Emerging antimicrobial resistance and need for antimicrobial stewardship for ocular infections in India: A narrative review

P Biswas, S Batra, N Gurha… - Indian Journal of …, 2022 - journals.lww.com
Patients with ocular infections are at increased risk of vision impairment and may require
immediate medical care to preserve their vision. Management of ocular bacterial infections …

Chitosan-poly (lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial …

S Ch, SG Padaga, B Ghosh, S Roy, S Biswas - Carbohydrate polymers, 2023 - Elsevier
A mucoadhesive self-assembling polymeric system was developed to carry moxifloxacin (M)
for treating bacterial keratitis (BK). Chitosan-PLGA (C) conjugate was synthesized, and …

Simultaneous determination of amphotericin B, tobramycin and vancomycin in rabbit ocular biofluids and tissues by LC-MS/MS: An antimicrobial therapy for keratitis …

A Mishra, A Biswas, AD Choudhury, S Verma… - … of Chromatography B, 2024 - Elsevier
A rationale poly-microbial keratitis (PMK) therapy requires quick identification of pathogen
(bacteria and fungi) and their efficient treatment. However, majority of healthcare providers …

Ciprofloxacin resistance and tolerance of Pseudomonas aeruginosa ocular isolates

M Khan, K Ma, I Wan, MDP Willcox - Contact Lens and Anterior Eye, 2023 - Elsevier
Purpose Tolerance to antibiotics may occur due to changes in bacterial growth patterns and
can be a precursor to development of resistance. However, there is a lack of information on …

Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis

C Peng, W Sun, C Zhou, S Qiang, M Jiang, JWY Lam… - Biomaterials, 2021 - Elsevier
Bacterial keratitis (BK) is one of the most commonly leading causes of visual impairment and
blindness worldwide, and suffers the risk of drug-resistant infections due to the abuse of …

Preparation and characterization of amphotericin B-loaded silk fibroin nanoparticles-in situ hydrogel composites for topical ophthalmic application

P Chomchalao, N Saelim, W Tiyaboonchai - Journal of Materials Science, 2022 - Springer
The objective of this study was to develop and characterize a novel combined systems of
amphotericin B-loaded silk fibroin nanoparticles (AmB-FNPs) and in situ hydrogel for ocular …

[HTML][HTML] Genipin in an ex vivo corneal model of bacterial and fungal keratitis

E Koudouna, M Huertas-Bello… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: To determine whether genipin (a natural crosslinker) could reduce the colonization
and proliferation of bacteria and fungi in an ex vivo model of corneal infection. Methods: This …

Delay along the care seeking journey of patients with microbial keratitis in Uganda

S Arunga, GM Kintoki, S Gichuhi, J Onyango… - Ophthalmic …, 2019 - Taylor & Francis
Purpose To describe the care seeking journey and causes of delay among patients with
Microbial Keratitis in Uganda. Methods A prospective cohort of patients presenting with …

Poly‐ε‐Lysine or Mel4 Antimicrobial Surface Modification on a Novel Peptide Hydrogel Bandage Contact Lens

R Lace, KG Doherty, D Dutta… - Advanced Materials …, 2020 - Wiley Online Library
Microbial keratitis (MK) is a serious issue in many countries and is often caused by contact
lens wear. Antimicrobial peptides (AMPs) are a potentially useful tool for creating …