Epigenetic changes and assisted reproductive technologies
ABSTRACT Children conceived by Assisted Reproductive Technologies (ART) are at
moderately increased risk for a number of undesirable outcomes, including low birth weight …
moderately increased risk for a number of undesirable outcomes, including low birth weight …
Recent developments in genetics and medically-assisted reproduction: from research to clinical applications
Two leading European professional societies, the European Society of Human Genetics and
the European Society for Human Reproduction and Embryology, have worked together …
the European Society for Human Reproduction and Embryology, have worked together …
[HTML][HTML] Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies
Background We analyzed placental DNA methylation levels at repeated sequences (LINE1
elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or …
elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or …
Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome
S Choufani, AL Turinsky, N Melamed… - Human molecular …, 2019 - academic.oup.com
Abstract Children conceived using Assisted Reproductive Technologies (ART) have a
higher incidence of growth and birth defects, attributable in part to epigenetic perturbations …
higher incidence of growth and birth defects, attributable in part to epigenetic perturbations …
Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation
Purpose Epidemiologic data suggest that in vitro fertilization (IVF) is associated with an
increased risk of disorders of placentation including preeclampsia and fetal growth …
increased risk of disorders of placentation including preeclampsia and fetal growth …
DNA methylation patterns within whole blood of adolescents born from assisted reproductive technology are not different from adolescents born from natural …
B Penova-Veselinovic, PE Melton… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do the epigenome-wide DNA methylation profiles of adolescents born
from ART differ from the epigenome of naturally conceived counterparts? SUMMARY …
from ART differ from the epigenome of naturally conceived counterparts? SUMMARY …
Embryo cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas
In vitro fertilization (IVF) is associated with DNA methylation abnormalities and a higher
incidence of adverse pregnancy outcomes. However, which exposure (s), among the many …
incidence of adverse pregnancy outcomes. However, which exposure (s), among the many …
[HTML][HTML] Comprehensive longitudinal study of epigenetic mutations in aging
Y Wang, R Karlsson, J Jylhävä, ÅK Hedman… - Clinical …, 2019 - Springer
Background The role of DNA methylation in aging has been widely studied. However,
epigenetic mutations, here defined as aberrant methylation levels compared to the …
epigenetic mutations, here defined as aberrant methylation levels compared to the …
[HTML][HTML] Epigenetic mutation load is weakly correlated with epigenetic age acceleration
DNA methylation (DNAm) age estimators are widely used to study aging-related conditions.
It is not yet known whether DNAm age is associated with the accumulation of stochastic …
It is not yet known whether DNAm age is associated with the accumulation of stochastic …
[HTML][HTML] Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome
Background Children conceived through assisted reproduction are at an increased risk for
growth and genomic imprinting disorders, often linked to DNA methylation defects. It has …
growth and genomic imprinting disorders, often linked to DNA methylation defects. It has …