[HTML][HTML] Integrating machine learning and multiscale modeling—perspectives, challenges, and opportunities in the biological, biomedical, and behavioral sciences

M Alber, A Buganza Tepole, WR Cannon, S De… - NPJ digital …, 2019 - nature.com
Fueled by breakthrough technology developments, the biological, biomedical, and
behavioral sciences are now collecting more data than ever before. There is a critical need …

[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Multiscale modeling meets machine learning: What can we learn?

GCY Peng, M Alber, A Buganza Tepole… - … Methods in Engineering, 2021 - Springer
Abstract Machine learning is increasingly recognized as a promising technology in the
biological, biomedical, and behavioral sciences. There can be no argument that this …

[HTML][HTML] Self-organized criticality in the brain

D Plenz, TL Ribeiro, SR Miller, PA Kells, A Vakili… - Frontiers in …, 2021 - frontiersin.org
Self-organized criticality (SOC) refers to the ability of complex systems to evolve toward a
second-order phase transition at which interactions between system components lead to …

[HTML][HTML] Systematic integration of structural and functional data into multi-scale models of mouse primary visual cortex

YN Billeh, B Cai, SL Gratiy, K Dai, R Iyer, NW Gouwens… - Neuron, 2020 - cell.com
Structural rules underlying functional properties of cortical circuits are poorly understood. To
explore these rules systematically, we integrated information from extensive literature …

BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

C Wang, T Zhang, X Chen, S He, S Li, S Wu - elife, 2023 - elifesciences.org
Elucidating the intricate neural mechanisms underlying brain functions requires integrative
brain dynamics modeling. To facilitate this process, it is crucial to develop a general-purpose …

[HTML][HTML] Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

SA Neymotin, DS Daniels, B Caldwell, RA McDougal… - Elife, 2020 - elifesciences.org
Magneto-and electro-encephalography (MEG/EEG) non-invasively record human brain
activity with millisecond resolution providing reliable markers of healthy and disease states …

[HTML][HTML] Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation

B Sagalajev, T Zhang, N Abdollahi, N Yousefpour… - Neuron, 2024 - cell.com
Electrically activating mechanoreceptive afferents inhibits pain. However, paresthesia
evoked by spinal cord stimulation (SCS) at 40–60 Hz becomes uncomfortable at high pulse …

Automated deep learning: Neural architecture search is not the end

X Dong, DJ Kedziora, K Musial… - … and Trends® in …, 2024 - nowpublishers.com
Deep learning (DL) has proven to be a highly effective approach for developing models in
diverse contexts, including visual perception, speech recognition, and machine translation …

Colloquium: Multiscale modeling of brain network organization

C Presigny, F De Vico Fallani - Reviews of Modern Physics, 2022 - APS
A complete understanding of the brain requires an integrated description of the numerous
scales and levels of neural organization. This means studying the interplay of genes and …