In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

抄録 In this review, after a summary of the history and current status of the receptors involved
in purinergic signalling, we focus on the distribution and physiological roles of purines and …

Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in
the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional …

There is widespread involvement of purinergic signalling in endocrine biology. Pituitary cells
express P1, P2X and P2Y receptor subtypes to mediate hormone release. Adenosine 5 …

Mitochondria are complex intracellular organelles that have long been identified as the
powerhouses of eukaryotic cells because of the central role they play in oxidative …

This review is focused on the most recent knowledge on growth control of rat thyroid cell
lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the …

In the human breast cancer cell line MCF-7, the nucleotides ATPγS and UTP, acting
extracellularly through the purinergic receptor P2Y2, lead to elevated intracellular calcium …

1. Introduction maturation of my conceptual understanding of the ATP permeabilizing
receptor because it reinforced and clarified I became familiar with extracellular ATP and ATP …

Extracellular nucleotides acting through specific P2 receptors activate intracellular signaling
cascades. Consistent with the expression of G protein-coupled P2Y receptors in skeletal …

Dynamic mechanical loading increases bone density and strength and promotes osteoblast
proliferation, differentiation and matrix production, by acting at the gene expression level …