Molecular photoswitches in aqueous environments

J Volarić, W Szymanski, NA Simeth… - Chemical Society …, 2021 - pubs.rsc.org
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

HDAC6 as a potential therapeutic target for peripheral nerve disorders

R Prior, L Van Helleputte, YE Klingl… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Peripheral neuropathies are a heterogeneous group of diseases that are
characterized by a progressive, ascending loss of nerve function arising from the peripheral …

Target design of novel histone deacetylase 6 selective inhibitors with 2-mercaptoquinazolinone as the cap moiety

HTB Bui, PH Nguyen, QM Pham, HP Tran, DQ Tran… - Molecules, 2022 - mdpi.com
Epigenetic alterations found in all human cancers are promising targets for anticancer
therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer …

Design, in silico studies, and synthesis of new 1, 8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects

VK Gurjar, D Pal - RSC advances, 2020 - pubs.rsc.org
New 1, 8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and
evaluated for their in vivo antihistaminic activity on guinea pig trachea by using …

Oxidative CO Cross‐Coupling of 1,3‐Dicarbonyl Compounds and Their Heteroanalogues with N‐Substituted Hydroxamic Acids and N‐Hydroxyimides

AO Terent'ev, IB Krylov, VP Timofeev… - Advanced Synthesis …, 2013 - Wiley Online Library
Abstract The oxidative C O cross‐coupling of 1, 3‐dicarbonyl compounds and their
heteroanalogues, 2‐substituted malononitriles and cyanoacetic esters, with N‐substituted …

Cracking a cancer code histone deacetylation in epigenetic: the implication from molecular dynamics simulations on efficacy assessment of histone deacetylase …

R Dushanan, S Weerasinghe… - Journal of …, 2022 - Taylor & Francis
Epigenetic changes, histone acetylation and deacetylation in chromatin have been
intensively studied due to their significance in regulating the gene expression. According to …

A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid

JP Mészáros, H Kovács, G Spengler, F Kovács… - Journal of Inorganic …, 2023 - Elsevier
Hydroxamic acids bearing an (O, O) donor set are well-known metal-chelating compounds
with diverse biological activities including anticancer activity. Since steroid conjugation with …

Laboratory detection and astronomical study of interstellar acetohydroxamic acid, a glycine isomer

M Sanz-Novo, JL Alonso, VM Rivilla… - Astronomy & …, 2022 - aanda.org
Aims. In this work, we aim to achieve the first laboratory detection of acetohydroxamic acid
(CH 3 CONHOH), a relevant glycine isomer, to enable its eventual identification in the ISM …

From α-nucleophiles to functionalized aggregates: exploring the reactivity of hydroxamate ion towards esterolytic reactions in micelles

N Singh, Y Karpichev, R Sharma, B Gupta… - Organic & …, 2015 - pubs.rsc.org
Owing to the rising threats of neurotoxic organophosphosphorus compounds, facile and
efficient decontamination systems are required. Since the last few decades, the search for …

Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing

M Israël, E Berg, G Tenenbaum - Journal of Clinical Medicine, 2023 - mdpi.com
In tumor cells, ketolysis “via” succinyl-CoA: 3-oxoacid-CoAtransferase (SCOT) and acetyl-
CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial acetyl-CoA. Active …