Molecular photoswitches in aqueous environments
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …
precision, using light as external stimulus, and hence are ideal tools for different research …
HDAC6 as a potential therapeutic target for peripheral nerve disorders
R Prior, L Van Helleputte, YE Klingl… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Peripheral neuropathies are a heterogeneous group of diseases that are
characterized by a progressive, ascending loss of nerve function arising from the peripheral …
characterized by a progressive, ascending loss of nerve function arising from the peripheral …
Target design of novel histone deacetylase 6 selective inhibitors with 2-mercaptoquinazolinone as the cap moiety
Epigenetic alterations found in all human cancers are promising targets for anticancer
therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer …
therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer …
Design, in silico studies, and synthesis of new 1, 8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects
New 1, 8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and
evaluated for their in vivo antihistaminic activity on guinea pig trachea by using …
evaluated for their in vivo antihistaminic activity on guinea pig trachea by using …
Oxidative CO Cross‐Coupling of 1,3‐Dicarbonyl Compounds and Their Heteroanalogues with N‐Substituted Hydroxamic Acids and N‐Hydroxyimides
AO Terent'ev, IB Krylov, VP Timofeev… - Advanced Synthesis …, 2013 - Wiley Online Library
Abstract The oxidative C O cross‐coupling of 1, 3‐dicarbonyl compounds and their
heteroanalogues, 2‐substituted malononitriles and cyanoacetic esters, with N‐substituted …
heteroanalogues, 2‐substituted malononitriles and cyanoacetic esters, with N‐substituted …
Cracking a cancer code histone deacetylation in epigenetic: the implication from molecular dynamics simulations on efficacy assessment of histone deacetylase …
R Dushanan, S Weerasinghe… - Journal of …, 2022 - Taylor & Francis
Epigenetic changes, histone acetylation and deacetylation in chromatin have been
intensively studied due to their significance in regulating the gene expression. According to …
intensively studied due to their significance in regulating the gene expression. According to …
A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid
JP Mészáros, H Kovács, G Spengler, F Kovács… - Journal of Inorganic …, 2023 - Elsevier
Hydroxamic acids bearing an (O, O) donor set are well-known metal-chelating compounds
with diverse biological activities including anticancer activity. Since steroid conjugation with …
with diverse biological activities including anticancer activity. Since steroid conjugation with …
Laboratory detection and astronomical study of interstellar acetohydroxamic acid, a glycine isomer
M Sanz-Novo, JL Alonso, VM Rivilla… - Astronomy & …, 2022 - aanda.org
Aims. In this work, we aim to achieve the first laboratory detection of acetohydroxamic acid
(CH 3 CONHOH), a relevant glycine isomer, to enable its eventual identification in the ISM …
(CH 3 CONHOH), a relevant glycine isomer, to enable its eventual identification in the ISM …
From α-nucleophiles to functionalized aggregates: exploring the reactivity of hydroxamate ion towards esterolytic reactions in micelles
Owing to the rising threats of neurotoxic organophosphosphorus compounds, facile and
efficient decontamination systems are required. Since the last few decades, the search for …
efficient decontamination systems are required. Since the last few decades, the search for …
Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing
M Israël, E Berg, G Tenenbaum - Journal of Clinical Medicine, 2023 - mdpi.com
In tumor cells, ketolysis “via” succinyl-CoA: 3-oxoacid-CoAtransferase (SCOT) and acetyl-
CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial acetyl-CoA. Active …
CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial acetyl-CoA. Active …