The emergence of antimicrobial resistance (AMR) across bacterial pathogens presents a
serious threat to global health. This threat is further exacerbated in tuberculosis (TB), mainly …

In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …

Tuberculosis (TB) remains the leading cause of deaths among infectious diseases
worldwide. Cutaneous Tuberculosis (CTB), caused by Mycobacterium tuberculosis (Mtb) …

The efficacy of the tuberculosis treatment is restricted by innate drug resistance of
Mycobacterial tuberculosis and its ability to acquire resistance to all anti-tuberculosis drugs …

Induction of mycobacterial efflux pumps is a cause of Mycobacterium tuberculosis (Mtb) drug
tolerance, a barrier to shortening antitubercular treatment. Verapamil inhibits Mtb efflux …

Programmed cell death protein 4 (PDCD4) is instrumental in regulating a range of cellular
processes such as translation, apoptosis, signal transduction, and inflammatory responses …

Highlights•The action of the efflux pump contributes to MDR-TB cases.•P-glycoprotein
reduces the bioavailability of anti-TB drugs.•Upregulation of angiogenic factors and P-gp …

Purpose Tuberculosis (TB) remains a major health threat worldwide, and the spread of drug-
resistant (DR) TB impedes the reduction of the global disease burden. Ebselen (EbSe) …

Multidrug efflux pumps excrete a range of small molecules from bacterial cells. In this study,
we show that bacterial efflux pumps have affinity for a range of SYTO™ dyes that are …

The rapid spread of drug-resistant M. tuberculosis (Mtb) strains and the phenomenon of
phenotypic tolerance to drugs present challenges toward achieving the goal of tuberculosis …