Intermediate filaments are critical for cell and tissue homeostasis and for stress responses.
Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect …

The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Hereditary dilated cardiomyopathy (DCM) is a primary disease of cardiac myocytes caused
by mutations in genes encoding proteins with a diverse array of functions. Mutations in the …

Plants cope with various recurring stress conditions that often induce DNA damage,
ultimately affecting plant genome integrity, growth, and productivity. The CROWDED …

Innovative methods to retrieve proteins associated with actively replicating DNA have
provided a glimpse into the molecular dynamics of replication fork stalling. We report that a …

Abstract The Repeat Expansion Diseases (REDs) are a large group of human genetic
disorders that result from an increase in the number of repeats in a disease-specific tandem …

Accurate transcription is required for the faithful expression of genetic information. However,
relatively little is known about the molecular mechanisms that control the fidelity of …

Lamin A, a main constituent of the nuclear lamina, is involved in mechanosignaling and cell
migration through dynamic interactions with the LINC complex, formed by the nuclear …

Besides the well-characterized protein network involved in the replication stress response,
several regulatory RNAs have been shown to play a role in this critical process. However, it …

Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome
stability. Dysfunctional telomeres are recognized as DSBs and are repaired by distinct DNA …