The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Background Today, lipid-based delivery systems (LBDS: emulsions, nanostructured lipid
carriers, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, and nanoliposomes) …

Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …

Highlights•We discuss the issue of poor drug solubility and its influence on formulation
development.•Co-amorphous systems have been studied widely as a way to improve the …

New drugs are frequently found with poor water-solubility in recent pharmaceutical projects,
which brings difficulties of bioavailability for the clinical development of new drugs. When …

Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities
due to their poorly aqueous solubilities and dissolutions. The aim of this study was to …

Rheumatoid arthritis (RA) is a chronic autoimmune joint disorder that affects about 1% of the
world population and may lead to severe disability and comorbidity. Despite breakthroughs …

Spray drying is a well-established technology to produce inhalable dry powders. However,
the amorphous nature of the particles typically obtained from the process can lead to …