▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

Evidence obtained from studies with yeast and Xenopusindicate that the initiation of DNA
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …

In all eukaryotic organisms, inappropriate firing of replication origins during the G2 phase of
the cell cycle is suppressed by cyclin-dependent kinases. Multicellular eukaryotes contain a …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

We report that a highly purified human origin recognition complex (HsORC) has intrinsic
DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds …

Eukaryotic cells possess overlapping mechanisms to ensure that DNA replication is
restricted to the S phase of the cell cycle. The levels of hOrc1p, the largest subunit of the …

The convergence point of growth regulatory pathways that control cell proliferation is the
initiation of genome replication, the core of which is the assembly of pre-replicative …

Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly
regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if …

The initiation of DNA replication in S phase requires the prior assembly of an origin
recognition complex (ORC)‐dependent pre‐replicative complex on chromatin during G1 …