DNA replication in eukaryotic cells
SP Bell, A Dutta - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …
replication of the entire genome each time a cell divides. To achieve this coordination …
Mechanisms and regulation of DNA replication initiation in eukaryotes
MW Parker, MR Botchan, JM Berger - Critical reviews in …, 2017 - Taylor & Francis
Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication …
J Méndez, B Stillman - Molecular and cellular biology, 2000 - Am Soc Microbiol
Evidence obtained from studies with yeast and Xenopusindicate that the initiation of DNA
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
JA Wohlschlegel, BT Dwyer, SK Dhar, C Cvetic… - Science, 2000 - science.org
In all eukaryotic organisms, inappropriate firing of replication origins during the G2 phase of
the cell cycle is suppressed by cyclin-dependent kinases. Multicellular eukaryotes contain a …
the cell cycle is suppressed by cyclin-dependent kinases. Multicellular eukaryotes contain a …
Regulating DNA replication in eukarya
K Siddiqui, KF On, JFX Diffley - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …
Sequence-independent DNA binding and replication initiation by the human origin recognition complex
S Vashee, C Cvetic, W Lu, P Simancek… - Genes & …, 2003 - genesdev.cshlp.org
We report that a highly purified human origin recognition complex (HsORC) has intrinsic
DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds …
DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds …
[HTML][HTML] Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication
Eukaryotic cells possess overlapping mechanisms to ensure that DNA replication is
restricted to the S phase of the cell cycle. The levels of hOrc1p, the largest subunit of the …
restricted to the S phase of the cell cycle. The levels of hOrc1p, the largest subunit of the …
DNA replication licensing and human cell proliferation
K Stoeber, TD Tlsty, L Happerfield… - Journal of cell …, 2001 - journals.biologists.com
The convergence point of growth regulatory pathways that control cell proliferation is the
initiation of genome replication, the core of which is the assembly of pre-replicative …
initiation of genome replication, the core of which is the assembly of pre-replicative …
The origin recognition complex: from simple origins to complex functions
SP Bell - Genes & Development, 2002 - genesdev.cshlp.org
Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly
regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if …
regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if …
[HTML][HTML] Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance
SG Prasanth, KV Prasanth, K Siddiqui… - The EMBO …, 2004 - embopress.org
The initiation of DNA replication in S phase requires the prior assembly of an origin
recognition complex (ORC)‐dependent pre‐replicative complex on chromatin during G1 …
recognition complex (ORC)‐dependent pre‐replicative complex on chromatin during G1 …