Glucose and related sugars repress the transcription of genes encoding enzymes required
for the utilization of alternative carbon sources; some of these genes are also repressed by …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Genome-wide expression analysis was used to identify genes whose expression depends
on the functions of key components of the transcription initiation machinery in yeast …

The recruitment model for gene activation stipulates that an activator works by bringing the
transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that …

The general transcription factors of RNA polymerase II. Publisher Logo Genes &
Development Skip to main page content HOME ABOUT SUBMIT SUBSCRIBE ADVERTISE …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …

The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose
component subunits were genetically linked to the RNA polymerase II (RNAPII) C-terminal …

▪ Abstract The last two decades have witnessed a tremendous expansion in our knowledge
of the mechanisms employed by eukaryotic cells to control gene activity. A critical insight to …

The form of RNA polymerase II (RNAPII) engaged in transcriptional elongation was isolated.
Elongating RNAPII was associated with a novel multisubunit complex, termed elongator …

Mechanisms controlling transcription and its regulation are fundamental to our
understanding of molecular biology and, ultimately, cellular biology. Our knowledge of …