Over the past decade, it has been shown that alternative splicing (AS) is a major mechanism
for the enhancement of transcriptome and proteome diversity, particularly in mammals …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

A common belief is that evolution generally proceeds towards greater complexity at both the
organismal and the genomic level, numerous examples of reductive evolution of parasites …

Collagens, or more precisely collagen-based extracellular matrices, are often considered as
a metazoan hallmark. Among the collagens, fibrillar collagens are present from sponges to …

The origin and early evolution of eukaryotes in the light of phylogenomics | Genome Biology
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Which genomic innovations underpinned the origin of multicellular animals is still an open
debate. Here, we investigate this question by reconstructing the genome architecture and …

There is massive variation in intron numbers across eukaryotic genomes, yet the major
drivers of intron content during evolution remain elusive. Rapid intron loss and gain in some …

In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …

Comparative genomics and systems biology offer unprecedented opportunities for testing
central tenets of evolutionary biology formulated by Darwin in the Origin of Species in 1859 …

Charles Darwin believed that all traits of organisms have been honed to near perfection by
natural selection. The empirical basis underlying Darwin's conclusions consisted of …