With a bang, a new family of potassium channels has exploded into view. Although KCNK
channels were discovered only five years ago, they already outnumber other channel types …

Potassium channels play important roles in vital cellular signaling processes in both
excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have …

The two-pore-domain K+ channels, or K2P channels, constitute a novel class of K+ channel
subunits. They have four transmembrane segments and are active as dimers. The tissue …

▪ Abstract Nonselective cation channels are a diverse group of ion channels characterized
by their low discrimination between many essential and toxic cations. They are ubiquitous in …

Mechano-sensitive and fatty acid-activated K+ belong to the structural class of K+ channel
with two pore domains. Here, we report the isolation and the characterization of a novel …

We have isolated from the rat cerebellum cDNA library a complementary DNA encoding a
new member of the tandem pore K+ channel family. Its amino acid sequence shares 54 …

Tandem pore domain acid-sensitive K+ channel 3 (TASK-3) is a new member of the tandem
pore domain potassium channel family. A cDNA encoding a 365-amino acid polypeptide …

Recently, several mammalian K+ channel subunits (TWIK, TREK-1, TRAAK, and TASK)
possessing four transmembrane segments and two pore-forming domains have been …

Despite widespread use of volatile general anesthetics for well over a century, the
mechanisms by which they alter specific CNS functions remain unclear. Here, we present …

Two cDNAs encoding novel K+ channels, THIK-1 and THIK-2 (tandem pore
domainhalothane inhibited K+ channel), were isolated from rat brain. The proteins of 405 …