Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …

Developing strategies that emulate the killing mechanism of neutrophils, which involves the
enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), shows …

Background Ischemic stroke is one of the main causes of death and disability in the world.
The treatment for ischemic stroke is to restore blood perfusion as soon as possible …

Nucleic acid-based therapy has emerged as a promising therapeutic approach for treating
various diseases, such as genetic disorders, cancers, and viral infections. Diverse nucleic …

Objectives We engineered a CRISPR interference (CRISPRi) system targeting the AcrAB-
TolC efflux pump to prevent MDR development in Escherichia coli. Methods Nine specific …

For most external applied antioxidant whitening ingredients, effective stratum corneum
breakthrough, epidermal penetration and dermal deposition are necessary premises for …

CRISPR, as an emerging gene editing technology, has been widely used in multiple fields
due to its convenient operation, less cost, high efficiency and precision. This robust and …

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated
proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing …

Nanomedicines have significantly advanced the development of diagnostic and therapeutic
strategies for various diseases, while they still encounter numerous challenges. Upon entry …