Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP
Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …
modern biomedical research. The opportunities to specifically modify and correct genomic …
Protein-based delivery systems for RNA delivery
H Zhu, H Luo, R Chang, Y Yang, D Liu, Y Ji… - Journal of Controlled …, 2023 - Elsevier
RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …
expression and generate therapeutic proteins or antigens capable of inducing immune …
Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy
Developing strategies that emulate the killing mechanism of neutrophils, which involves the
enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), shows …
enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), shows …
Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice
D Liu, Q Ji, Y Cheng, M Liu, B Zhang, Q Mei… - Journal of …, 2022 - Springer
Background Ischemic stroke is one of the main causes of death and disability in the world.
The treatment for ischemic stroke is to restore blood perfusion as soon as possible …
The treatment for ischemic stroke is to restore blood perfusion as soon as possible …
Bioengineered nanotechnology for nucleic acid delivery
Nucleic acid-based therapy has emerged as a promising therapeutic approach for treating
various diseases, such as genetic disorders, cancers, and viral infections. Diverse nucleic …
various diseases, such as genetic disorders, cancers, and viral infections. Diverse nucleic …
Engineering a CRISPR interference system targeting AcrAB-TolC efflux pump to prevent multidrug resistance development in Escherichia coli
X Wan, Q Li, RH Olsen, H Meng, Z Zhang… - Journal of …, 2022 - academic.oup.com
Objectives We engineered a CRISPR interference (CRISPRi) system targeting the AcrAB-
TolC efflux pump to prevent MDR development in Escherichia coli. Methods Nine specific …
TolC efflux pump to prevent MDR development in Escherichia coli. Methods Nine specific …
High skin permeation, deposition and whitening activity achieved by xanthan gum string vitamin c flexible liposomes for external application
X Lv, Z Wu, X Qi - International Journal of Pharmaceutics, 2022 - Elsevier
For most external applied antioxidant whitening ingredients, effective stratum corneum
breakthrough, epidermal penetration and dermal deposition are necessary premises for …
breakthrough, epidermal penetration and dermal deposition are necessary premises for …
[HTML][HTML] Intelligent nanotherapeutic strategies for the delivery of CRISPR system
C Chen, W Zhong, S Du, Y Li, Y Zeng, K Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
CRISPR, as an emerging gene editing technology, has been widely used in multiple fields
due to its convenient operation, less cost, high efficiency and precision. This robust and …
due to its convenient operation, less cost, high efficiency and precision. This robust and …
Editing SOX Genes by CRISPR-Cas: Current Insights and Future Perspectives
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated
proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing …
proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing …
Manipulation of protein corona for nanomedicines
T Li, Y Wang, D Zhou - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Nanomedicines have significantly advanced the development of diagnostic and therapeutic
strategies for various diseases, while they still encounter numerous challenges. Upon entry …
strategies for various diseases, while they still encounter numerous challenges. Upon entry …