Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy

JL Carter, K Hege, J Yang, HA Kalpage, Y Su… - Signal transduction and …, 2020 - nature.com
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

K Natarajan, Y Xie, MR Baer, DD Ross - Biochemical pharmacology, 2012 - Elsevier
Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

[HTML][HTML] Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression

T Nakanishi, DD Ross - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

Molecular pharmacology of ABCG2 and its role in chemoresistance

AE Stacy, PJ Jansson, DR Richardson - Molecular pharmacology, 2013 - ASPET
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …

[HTML][HTML] Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

IM Bouligny, KR Maher, S Grant - Blood reviews, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

[HTML][HTML] Drug resistance mechanisms of acute myeloid leukemia stem cells

J Niu, D Peng, L Liu - Frontiers in Oncology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …

Concise review: chronic myeloid leukemia: stem cell niche and response to pharmacologic treatment

E Arrigoni, M Del Re, S Galimberti… - Stem cells …, 2018 - academic.oup.com
Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …

[HTML][HTML] Resistance to chemotherapy is associated with altered glucose metabolism in acute myeloid leukemia

K Song, M Li, X Xu, LI Xuan, G Huang… - Oncology …, 2016 - spandidos-publications.com
Altered glucose metabolism has been described as a cause of chemoresistance in multiple
tumor types. The present study aimed to identify the expression profile of glucose …

Resistance of leukemic stem-like cells in AML cell line KG1a to natural killer cell-mediated cytotoxicity

M She, X Niu, X Chen, J Li, M Zhou, Y He, Y Le, K Guo - Cancer letters, 2012 - Elsevier
Leukemic stem cells (LSCs) play the central role in the relapse and refractory of acute
myeloid leukemia (AML) and highlight the critical need for the new therapeutic strategies to …

Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

Y Zhang, H Chen, S Zhou, S Wang, K Zheng, D Xu… - Molecular cancer, 2015 - Springer
Background Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-
renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and …