Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung
cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of …

ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

Although treatment with taxanes does not always lead to clinical benefit, all patients are at
risk of their detrimental side effects such as peripheral neuropathy. Understanding the in …

Paclitaxel and docetaxel are active against a range of human cancers. Their antitumor
activity is based on stabilization of the microtubule dynamics and thereby disruption of the …

Nine proteins of the ABC superfamily (P-glycoprotein, 7 MRPs and BCRP) are involved in
multidrug transport. Being localised at the surface of endothelial or epithelial cells, they …

ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the
canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of …

The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins
and assess the functional significance of 17 variants in five genes involved in drug …

The ATP-binding-cassette (ABC) transporter multidrug resistance protein (MRP) 2 (ABCC2)
forms a natural barrier and efflux system for various (conjugates of) drugs, other xenotoxins …

ATP-binding cassette (ABC) transporters are transmembrane efflux transporters that mediate
cellular extrusion of a broad range of substrates ranging from amino acids, lipids, and ions to …