We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …

High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory
dysfunction. Patients living with such conditions often rely on ventilatory assistance to …

An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a
persistent increase in phrenic burst amplitude following acute intermittent hypoxia (AIH) …

Hypotheses Moderate acute intermittent hypoxia (mAIH) elicits plasticity in both respiratory
(phrenic long-term facilitation; pLTF) and sympathetic nerve activity (sympLTF) in rats …

Plasticity is a hallmark of the respiratory neural control system. Phrenic long-term facilitation
(pLTF) is one form of respiratory plasticity characterized by persistent increases in phrenic …

Abstract Low-dose (< 2 h/day), acute intermittent hypoxia (AIH) elicits multiple forms of
serotonin-dependent phrenic motor plasticity and is emerging as a promising therapeutic …

More than half of all spinal cord injuries (SCIs) occur at the cervical level and often lead to
life-threatening breathing motor dysfunction. The C2 hemisection (C2Hx) and high cervical …

Cervical spinal cord injury (cSCI) impairs neural drive to the respiratory muscles, causing life-
threatening complications such as respiratory insufficiency and diminished airway …

Acute intermittent hypoxia (AIH) elicits spinal neuroplasticity and is emerging as a potential
therapeutic modality to improve respiratory and non-respiratory motor function in people with …