Several contemporary enzymes catalyze alternative reactions distinct from their normal
biological reactions. In some cases the alternative reaction is similar to a reaction that is …

Proteins play an essential role in biology. Whether it is in catalysis or molecular recognition,
proteins set a golden standard of efficiency and selectivity that few other natural or artificial …

To clarify how the location of distal histidine affects the activation process of H 2 O 2 by
heme proteins, we have characterized reactions with H 2 O 2 for the L29H/H64L and …

Described herein is the synthesis of the NiII complex (t BuMe2tacn) NiII (cycloneophyl)(t
BuMe2tacn= 1-tert-butyl-4, 7-dimethyl-1, 4, 7-triazacyclononane, cycloneophyl=− CH2CMe2 …

Oxidation of the PdII complex (N4) PdIIMe2 (N4= N, N′-di-tert-butyl-2, 11-diaza [3.3](2, 6)
pyridinophane) with O2 or ROOH (R= H, tert-butyl, cumyl) produces the PdIII species [(N4) …

To pursue structure− function relationships of heme enzymes in the activation of peroxides,
we have chosen to use myoglobin as the framework for our molecular engineering studies …

Peroxidases are ubiquitous enzymes that catalyze a variety of enantioselective oxygen-
transfer reactions with hydrogen peroxide (H 2 O 2). Although they have enormous potential …

Metal-binding sites have been engineered into both de novo designed and naturally
occurring proteins. Although the redesign of existing metal-binding sites in naturally …

To examine the roles of the axial thiolate in cytochrome P450-catalyzed reactions, a mutant
of cytochrome P450cam, L358P, was prepared to remove one of the conserved amide …

Peroxidase activity of a myoglobin reconstituted with a chemically modified heme 1 is
reported. The heme 1 bearing a total of eight carboxylates bound to the terminal of …