Neuropsychiatric disorders and type 2 diabetes (T2D) are major public health concerns
proposed to be intimately connected. T2D is associated with increased risk of dementia …

Introduction: Selective agonists of the nuclear transcription factor peroxisome proliferator-
activated receptor-gamma (PPAR-γ) are used for the treatment of type 2 diabetes. We …

OBJECTIVE Diabetes is associated with an increased risk of depression. Some antidiabetes
agents, specifically metformin and pioglitazone, have been suggested to have beneficial …

Insulin-sensitizing medications were originally used in psychiatric practice to treat weight
gain and other metabolic side effects that accompany the use of mood stabilizers …

Depression is a common comorbidity in diabetes but conventional antidepressant
treatments do not consistently improve outcomes. We tested whether established diabetes …

Recently, peroxisome proliferator-activated receptor (PPAR)-α and γ isoforms have been
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …

Close connections between depression and type 2 diabetes (T2DM) have been suggested
by many epidemiological and experimental studies. Disturbances in insulin sensitivity due to …

Depression is a major psychiatric disease affecting all ages and is often co-morbid with
neurodegeneration in the elderly. Depression and neurodegeneration are associated with …

Insulin resistance and impaired lipoprotein metabolism contribute to a plethora of metabolic
and cardiovascular disorders. These alterations have been extensively linked with poor …

Women around menopause are vulnerable to present psychiatric and metabolic disorders;
thus, therapies that contribute to treat both pathologies are required. Previous reports …